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. Author manuscript; available in PMC: 2017 Jan 17.
Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2004 Feb 5;287(2):G417–G424. doi: 10.1152/ajpgi.00294.2003

Fig. 7.

Fig. 7

Extracellular UDP regulates transcription of a(1)-procollagen in activated HSC via P2Y receptor activation. Real-time RT-PCR was used to determine procollagen-1 mRNA content in day 7 HSC treated under the following conditions: control (vehicle alone), suramin (50 mM), UDP (100 mM), or UDP + suramin. Suramin had no significant effect on procollagen-1 mRNA content. However, addition of UDP roughly tripled procollagen-1 mRNA, and this was partially inhibited by suramin addition (*P < 0.01 vs. control; **P < 0.05 vs. UDP, P < 0.05 vs. control; ‡P = not significant vs. control; n = 3 for all groups).