Figure 3. Endocrine Transcriptomes Reveal Novel Expression Patterns of Key Genes.
(A) Violin plots for expression of UCN3, FFAR4, LEPR, IAPP, and DLK1 across alpha, beta, gamma, and delta cell types for all human donors (left) and two mice (right). The percent number indicates the fraction of cells with detectable expression of the gene.
(B) FFAR4 (GPR120) is expressed in delta and beta cells of human islet cells. C-peptide and Somatostatin mark beta and delta cells, respectively. Note the co-positive yellow cells in both merged images showing FFAR4 expression in both beta and delta cells.
(C) Heatmap showing gene expression of transcription factors across the human (left) and mouse (right) endocrine cell types.