TABLE 3.
In vitro susceptibilities of opportunistic non-Candida yeast-like fungi to new and established antifungal agents determined by NCCLS M27-A2 broth dilution MIC methodsa
| Species | Antifungal agent | No. of isolates tested | MIC (μg/ml)
|
Reference | ||
|---|---|---|---|---|---|---|
| Range | 50% | 90% | ||||
| T. asahii | Amphotericin B | 43 | 1-8 | 4 | 4 | 2 |
| Fluconazole | 43 | 0.25-16 | 2 | 8 | 2 | |
| Itraconazole | 43 | 0.06-4 | 0.5 | 1 | 2 | |
| Ravuconazole | 24 | 0.25->16 | 0.5 | NAb | 75 | |
| Posaconazole | 24 | 0.06->16 | 0.12 | NA | 75 | |
| Voriconazole | 24 | 0.03->16 | 0.25 | NA | 75 | |
| Non-T. asahii | Amphotericin B | 15 | 0.06-1 | 0.25 | NA | 75 |
| Fluconazole | 15 | 0.5-4 | 2 | NA | 75 | |
| Itraconazole | 15 | 0.03-0.5 | 0.12 | NA | 75 | |
| Ravuconazole | 15 | 0.03->16 | 0.5 | NA | 75 | |
| Posaconazole | 15 | 0.03-0.5 | 0.12 | NA | 75 | |
| Voriconazole | 15 | 0.03-0.25 | 0.06 | NA | 75 | |
| T. beigelii | Amphotericin B | 5 | 0.5-2 | 2 | NDc | 25 |
| Fluconazole | 5 | 1-2 | 2 | ND | 25 | |
| Itraconazole | 5 | 0.06-0.25 | 0.25 | ND | 25 | |
| Posaconazole | 5 | 0.12-1 | 1 | ND | 24 | |
| Voriconazole | 5 | <0.03-0.12 | <0.03 | ND | 25 | |
| Caspofungin | 5 | 16->16 | >16 | ND | 24 | |
| Anidulafungin | 5 | >16 | >16 | ND | 24 | |
| Rhodotorula spp. | Amphotericin B | 35 | 0.12-0.5 | 0.25 | 0.5 | 28 |
| Flucytosine | 35 | 0.06-0.25 | 0.12 | 0.25 | 28 | |
| Fluconazole | 35 | 32-256 | 256 | 256 | 28 | |
| Itraconazole | 35 | 0.25-1 | 1 | 1 | 28 | |
| Posaconazole | 54 | 0.25->8 | 2 | 4 | 21 | |
| Ravuconazole | 56 | 0.015-2 | 0.25 | 1 | 21 | |
| Voriconazole | 55 | 0.25->8 | 2 | 4 | 21 | |
| Caspofungin | 55 | 8->8 | >8 | >8 | 21 | |
| Micafungin | 10 | >64 | >64 | >64 | 113 | |
| Geotrichum capitatum | Amphotericin B | 23 | 0.06-0.25 | 0.12 | 0.12 | 30 |
| Flucytosine | 23 | 0.12-16 | 0.12 | 4 | 30 | |
| Fluconazole | 23 | 1-32 | 8 | 8 | 30 | |
| Itraconazole | 23 | 0.03-0.5 | 0.12 | 0.25 | 30 | |
| Voriconazole | 23 | 0.03-0.5 | 0.25 | 0.25 | 30 | |
| Anidulafungin | 4 | 1-4 | 4 | ND | 6 | |