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Incidence of diabetes in immunodeficient NOD mice expressing exclusively the BDC2.5 TCR transgene. Cumulative diabetes incidence in NOD BDC2.5 transgenic mice. NOD BDC2.5 Cα-/- mice or NOD BDC2.5 Rag-/- mice were backcrossed 7 (A)or >12 (B) times onto the NOD background. Introduction of the BDC2.5 TCR transgene into T cell-deficient NOD mice strongly accelerated the onset of diabetes. NOD BDC2.5 SCID mice showed a diabetes incidence identical to NOD BDC2.5 Rag-/- mice.
