TABLE 2.
Summary of the M83+/− mice i.m. injected
| Inoculum | Predetermined endpoint (dpi) | No. of animals paralyzed/no. injected | No. of animals with αS pathology/no. analyzed | CNS distribution of αS pathology |
|---|---|---|---|---|
| mfib αS | NAa | 13/17b | 17/17 | Predominantly thalamus, hypothalamus, periaqueductal gray, brain stem, and SC |
| Human soluble αS | 270 | 7/8c | 7/8c | Predominantly thalamus, hypothalamus, periaqueductal gray, brain stem, and SC |
| Human Δ71-82 αS | 240 | 2/17 | 5/17 | Predominantly periaqueductal gray, brain stem, and SC. Sparse in thalamus and hypothalamus |
| Human βS | 300 | 0/6 | 0/6 | None |
| KLH | 220 | 0/8 | 0/8 | None |
a
NA, not applicable.
b
Four mice had to be euthanized for non-motor-impaired health complications at 98, 107, 107, and 112 dpi (i.e., fighting wounds).
c
One mouse had to be euthanized for non-motor-impaired health complications at 262 dpi (i.e., fighting wounds).