Fig. 6.
Population PBPK model prediction of lidocaine arterial plasma concentrations during and after a constant-rate i.v. infusion (lidocaine HCl, 3 mg/kg for 3 minutes). The clinically observed data represented with closed gray circles were extracted from Tucker and Boas (1971) across five different subjects. The shaded area corresponds to the 95% population prediction intervals of the model, and the red line corresponds to the median model prediction. The insert plot magnifies the first 16 minutes for the purpose of clarity.