. 2016 Dec 16;91(1):e01825-16. doi: 10.1128/JVI.01825-16

TABLE 4.

Pathology scores of lungs of mice depleted of CD4⁺ T cells and infected with 2.5 × 10⁴ PFU MERS-CoV(Jordan)^a

Pathological sign	Mean pathology score of animals treated with indicated antibody
	Mock infection				MERS-CoV infection
	4 dpi		7 dpi		4 dpi		7 dpi
	IgG	Anti-CD4	IgG	Anti-CD4	IgG	Anti-CD4	IgG	Anti-CD4
Overall inflammation	+	+	+	+	++	++	++	++
Bronchiolar inflammation	+	+	+	+	++	++	++	++
Perivascular inflammation	+	+	+	+	++	++	++	++
Edema	+	+	+	+	+	+	+	+
Eosinophils	+	+	+	+	++	+	++	+
Neutrophils	+	+	+	+	++	+	+	+
Macrophages	+	+	+	+	++	++	++	++
Lymphocytes	+	+	+	+	++	++	++	++
Pleuritis	+	+	+	+	+	++	+	+
Epithelial necrosis	+	+	+	+	+	+	+	+

Lung sections from 5 MERS-CoV-infected mice per group were scored for pathological signs of disease on a scale of 0 to 5, and scores were averaged and rounded to the nearest whole number: +, 0 or 1; ++, 2 or 3; +++, 4 or 5; dpi, days postinfection.