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. Author manuscript; available in PMC: 2017 May 16.
Published in final edited form as: Nature. 2016 Nov 16;539(7630):588–592. doi: 10.1038/nature20162

Figure 3. Nibbler and Zucchini set the balance between primary and secondary piRNA biogenesis.

Figure 3

a) Schematic of the two-pathway model for piRNA 3' end formation.

Panels b-c show scatter plots based on piRNAs mapping to germline-dominant TEs (n=63).

b) Plotted are Z-scores of piRNA 3'/5' coupling in w1118 versus nibbler-/- ovaries (orange: Aub-bound antisense piRNA 3' ends to Piwi-bound piRNA 5' ends; blue: Ago3-bound sense piRNA 3' ends to Piwi-bound piRNA 5' ends).

c) Plotted are normalized contributions of Piwi/Aub/Ago3-bound piRNAs to total TE piRNA profiles in w1118 versus nibbler-/- ovaries. Stacked bar plots show sum for all analyzed TEs.