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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Oct 12;1864(1):23–30. doi: 10.1016/j.bbamcr.2016.10.005

Figure 1. ITSN short and long isoforms.

Figure 1

Human ITSN is comprised by 2 EH domains, 1 CC domain and 5 SH3 domains. Additionally, the long isoform contains a DH, a PH and a C2 domain. Both short and long isoforms are also found in mice. Invertebrates usually lack the long isoform, as shown in the worm C. elegans. Besides, some organisms as Drosophila only exhibit 4 SH3 domains. The pathogenic fungus C. neoformans is an exception, since the DH and PH domains are present in its structure. Furthermore, it contains a single EH domain and 2 SH3 domains, with an additional WH2 domain. Abbr: H. sapiens: Homo sapiens; M. musculus: Mus musculus; C. elegans: Caenorhabditis elegans; D. melanogaster: Drosophila melanogaster; C. neoformans: Cryptococcus neoformans.