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. 2016 Nov 7;126(12):4626–4639. doi: 10.1172/JCI88606

Figure 2. An HFD induces the accumulation of PD-1+CD44hiCD4+ T cells in VAT.

Figure 2

WT mice were fed an HFD for 14 weeks beginning at 4 weeks of age. Age-matched WT mice fed an ND were used as controls. (A) Analysis of VAT PD-1+CD44hiCD4+ cells (n = 5–6 mice per group). Data represent the mean ± SEM. *P < 0.05 and **P < 0.001, by 2-tailed Student’s t test. (B) Histological analyses of VAT. Adipocytes (BODIPY, red), PD-1 (yellow), nuclei (DAPI, blue), and CD3 (pink). Scale bars: 100 μm.