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. Author manuscript; available in PMC: 2017 Apr 17.
Published in final edited form as: Nat Chem Biol. 2016 Oct 17;12(12):1004–1006. doi: 10.1038/nchembio.2207

Figure 2. Discovery and screening of the humimycins.

Figure 2

a) The humimycins were predicted from closely related gene clusters found in two Rhodococcus spp. cultured from human subjects. b) Chemical structures of humimycin A (1) and B (2). The two antibiotics differ only at the fourth (F/Y) and sixth (V/I) residues. c) MIC values for the humimycins against a panel of human commensal and pathogenic bacteria were determined (n = 2). The right panel shows that the humimycins are particularly active against bacteria in the Staphylococcus and Streptococcus genus (n = 3).