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. 2016 Apr 5;7(19):28000–28012. doi: 10.18632/oncotarget.8584

Table 1. Patient characteristics with respect to overall survival.

Variables	Training cohort			Validation cohort
	Univariate^a	Multivariate^b		Univariate^a	Multivariate^b
	P value	HR (95% CI)	P value	P value	HR (95% CI)	P value
Age, years (> 50)	0.850			0.367
Gender (Male)	0.629			0.080
Maximal tumor size (> 5 cm)	0.006		0.479	0.014		0.637
Tumor number (≥ 2)	0.160			0.489
Tumor differentiation (Poor)	0.303			0.020		0.267
PVTT (Yes)	< 0.001		0.071	0.004		0.117
TNM stage (I/II/III/IV)	< 0.001	1.880 (1.177–3.003)	0.008	0.002	1.931 (1.047–3.561)	0.035
miR-452expression (low/high)	< 0.001	2.907 (1.494–5.658)	0.002	0.001	2.313 (1.144–4.676)	0.020

^a

univariate cox regression analysis;

^b

multivariate cox regression analysis;