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. 2016 Apr 5;7(19):28000–28012. doi: 10.18632/oncotarget.8584

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Copyright: © 2016 Zheng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) The percentage of CD44+ and CD133+ cells markedly increased upon miR-452 up-regulation both in LM3 and Huh7. (B) MiR-452 overexpressed HCC cells showed higher chemoresistance to doxorubicin and sorafenib. (C) The self-renewal capability of LM3 and Huh7 was significantly enhanced after miR-452 expression increased in tumor sphere assay. (D) miR-452 efficiently promoted HCC invasion in vitro. (E) The capability of tumorigenicity significantly enhanced both in the primary and secondary xenograft model of LM3/miR-452 cells in comparison with LM3/NC cells. (F) In vivo metastasis assay, miR-452 distinctly aggravated the metastasis of LM3 cells (n = 5).