Table II.
Examples of DNA-launched live-attenuated vaccine viruses.
| Virus Family | Vaccine | Dose, In vitro | Dose, In vivo | Vaccine Route | Viremia | Neutralizing Antibody | Protection | Reference |
|---|---|---|---|---|---|---|---|---|
| Alpha virus | CHIKV | 5 ng | 10 μg | IM/EP | +/- | + (10/10) | + (10/10) | [19] |
| VEEV | 8 ng | 50 μg | IM/EP | +/- | + (10/10) | + (10/10) | [20] | |
| 10 μg | IV | +/- | + | |||||
|
| ||||||||
| Flavi virus | WNV | 0.1-10 μg | IM | + | + | + | [22, 24, 99, 101] | |
| JEV | 2 μg | nt | n/a | n/a | n/a | n/a | [23, 103] | |
| YFV | 10 ng | 20 μg | IM/EP | - | + (10/10) | nt | [21] | |
| 5 μg | 0.1-10 μg | IM/EP | + | + | nt | [31] | ||
CHIKV, Chikungunya virus; VEEV, Venezuelan equine encephalitis virus; WNV, West Nile virus; JEV, Japanese encephalitis virus; YFV, yellow fever virus; IM, intramuscular; IM/EP, intramuscular/electroporation; IV, intravenous; nt, not tested; n/a, not applicable.