. 2016 Mar 23;7(17):24284–24302. doi: 10.18632/oncotarget.8301

Table 1. The top 25 up-regulated genes that are induced greater than 2-fold by a combination of loss of Rb and hypoxia when compared to negative controls.

Gene Name	Probe Name	Fold Induction (vs shSCX-N)			Hypoxia Inducible/HIF1-regulated
Gene Name	Probe Name	shRb-N	shSCX-HYP	shRb-HYP	Hypoxia Inducible/HIF1-regulated
HTR5A	A_23_P42565	2.07	27.41	256.40	[44]
PLOD2	A_33_P3318581	2.53	24.26	219.02	[9, 42, 44]
SLC16A3	A_23_P158725	1.73	24.85	200.17	[45]
ATP4A	A_23_P430728	2.46	12.53	157.93	^*
PLA2G4D	A_33_P3361611	1.15	10.05	97.72	^*
NIM1	A_23_P254863	1.32	5.73	91.57	^*
CYP26A1	A_23_P138655	1.15	2.87	68.51	^*
CXCR4	A_23_P102000	1.30	2.65	62.56	[43]
KISS1R	A_33_P3231357	0.61	8.51	61.94	^*
ANGPTL4	A_33_P3295358	1.92	3.63	53.17	[39, 44]
GPR26	A_23_P305581	0.98	9.84	53.00	^*
MYBPC2	A_33_P3257182	1.18	3.74	50.39	^*
FOS	A_23_P106194	1.47	1.41	49.01	[44]
PPFIA4	A_23_P420692	1.61	8.32	39.76	[47]
CA9	A_23_P157793	1.18	2.09	28.63	[42, 44, 48]
NFATC4	A_33_P3250083	1.52	4.70	21.97	[42]
PFKFB4	A_24_P362904	1.53	2.94	21.82	[41, 42, 44]
PCP4L1	A_32_P214665	1.97	2.51	21.02	^*
RORA	A_23_P26124	1.40	2.57	20.81	[40]
AMPD3	A_24_P304154	0.91	0.89	19.43	^*
ALDOC	A_23_P78108	1.46	4.85	19.33	[42, 44]
ENO2	A_24_P236091	1.80	2.61	19.09	[42]
SCNN1G	A_23_P206626	1.10	1.30	19.01	^*
STC1	A_23_P314755	1.10	4.42	19.00	[38]
NDRG1	A_23_P20494	1.19	6.80	18.60	[37, 46]

The (*) denotes genes containing putative HREs identified in the in silico consensus ARNT:HIF1α binding sequence analysis (Supplementary Data File 1).