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. 2016 May 14;73(20):3861–3885. doi: 10.1007/s00018-016-2268-0

Table 1.

Transcription factors regulating inflammation and proliferation in skin wound healing

Transcription factor Inflammation Proliferation References
Re-epithelialization Granulation tissue Angiogenesis
GRs − − − [138, 139]
ARs + − [140–143]
ERs − + [144–147]
PPARs − + [149–151]
AP-1 − + [152–155]
E2F1 + + [157]
Smad2 − [159]
Smad3 + −/+ [160–162]
Smad4 − +/− [163, 164]
Smad7 − + − [165]
EGR1 + + + + [166–168]
HoxD3 + + + [171]
HoxA3 + + + [172]
HoxB13 + − + [173, 174]

+ positive regulation, − negative regulation