Fig. 2. TgβARKrgs mice exhibit a similar decrease in cardiac hypertrophy as TgGqI mice after TAC.
(A to F) TgβARKrgs and nontransgenic littermate control sham (Sh) and post-TAC animals were analyzed at baseline and at 2 and/or 4 weeks after surgery. Percent left ventricular ejection fraction (A). Serial measures for left ventricular (LV) posterior wall thickness during systole (LVPWs) (B), diastole (LVPWd) (C), and left ventricular mass (D). Measures of heart weight (HW) normalized to tibia length (TL) (HW/TL) (E) and left atrial weight (F) 4 weeks after surgery. (G and H) TgGqI and nontransgenic sham and post-TAC animals were analyzed at baseline and at 2 and/or 4 weeks after surgery. Serial measures for LVPWs (G) and LV mass (H). (I) Measures of HW/TL. *P = 0.01; **P = 0.001; ***P < 0.0001 as determined by two-way ANOVA with repeated measures and Bonferroni post hoc test for (A) to (D) and (G) to (H) and by one-way ANOVA with Tukey post hoc test for (E), (F), and (I) relative to nontransgenic sham mice. τP = 0.01; τττP < 0.0001 by two-way ANOVA with repeated measures and Bonferroni post hoc test relative to nontransgenic TAC mice. tP = 0.01 by one-way ANOVA with Tukey post hoc test relative to nontransgenic TAC mice. n = 10 to 16 mice per group for (A) to (I).