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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: J Mol Biol. 2016 May 12;428(17):3495–3513. doi: 10.1016/j.jmb.2016.04.032

Figure 3. Distinct models to account for the role of GBPs in inflammasome activation.

Figure 3

Three non-mutually exclusive models provide a conceptual framework for the function of GBPs in inflammasome activation: 1) GBPs promote the lysis of S. typhimurium-containing vacuoles thereby releasing the pathogen into the host cell cytosol; 2) GBPs bind to and lyse cytosolic F. novicida prompting the spillage of bacterial DNA into the host cell cytosol; 3) GBPs accelerate the kinetics of caspase-11 and/or caspase-1 oligomerization.