Fig. 4.
Schematic diagram depicting multiple chymase actions including direct breakdown of laminin and fibronectin important in cell survival (82), activation of matrix metalloproteinases (MMPs) (139), TGF-β (152), stem cell factor (SCF) (86), kallikrein and chemotaxis (50), IL-6 and IL-1β (91), pre-proendothelin I (pre-proET1) (74, 124), and activation of other growth factors and enzymes in tissue injury. BK, bradykinin.
