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. 2016 May 27;311(2):H404–H414. doi: 10.1152/ajpheart.00219.2016

Fig. 4.

Fig. 4.

Schematic diagram depicting multiple chymase actions including direct breakdown of laminin and fibronectin important in cell survival (82), activation of matrix metalloproteinases (MMPs) (139), TGF-β (152), stem cell factor (SCF) (86), kallikrein and chemotaxis (50), IL-6 and IL-1β (91), pre-proendothelin I (pre-proET1) (74, 124), and activation of other growth factors and enzymes in tissue injury. BK, bradykinin.