Figure 2.
Select axial slices showing regions in which the imaging metric R2 was significantly associated with rate of change in global cognition and each of four cognitive domains, after accounting for demographics and neuropathologic indices of Alzheimer’s disease, cerebrovascular disease, and Lewy body disease. All regions exhibited lower (slower) R2 values corresponding to more rapid cognitive decline, except for the small region in the putamen for semantic memory (white arrow), which exhibited elevated (faster) R2 values corresponding to faster cognitive decline. Colors indicate the portion of variance in cognitive decline accounted for by the R2 value of a given voxel, beyond that accounted for by neuropathologic indices. The grayscale underlay is the R2-weighted study specific template. GL = global cognition, EP = episodic memory, SE = semantic memory, WO = working memory, PS = perceptual speed. [COLOR FIGURE]