Table S2.
Comparison of amino acid residues lining the VP1 hydrophobic pocket among enteroviruses
| Residues | RV-C15a | RV-A16 (1AYM) | RV-B14 (4RHV) | EV-A71 (3ZFE) | CVB3 (1COV) | PV1 (1ASJ) | EV-D68 (4WM8) |
| Head | |||||||
| 1096 | Phe | Leu | Leu | Ile | Pro | Tyr | Thr |
| 1106 | Phe | Phe | Leu | Val | Leu | Leu | Leu |
| 1114 | Phe | Phe | Phe | Phe | Phe | Phe | Phe |
| 1178 | Tyr | Tyr | Tyr | Tyr | Tyr | Tyr | Tyr |
| 1180 | Met | Met | Cys | Trp | Asn | His | Val |
| 1198 | Ile | Thr | Ile | Ala | Ile | Ala | Ile |
| 1246 | Tyr | His | Gly | Ala | Lys | — | Ala |
| Middle part | |||||||
| 1080 | Trp | Ile | Val | Val | Val | Val | Val |
| 1092 | Trp | Trp | Trp | Trp | Trp | Trp | Trp |
| 1094 | Ile | Ile | Ile | Ile | Ile | Ile | Ile |
| 1116 | Met | Ser | Ser | Ala | Leu | Met | Ala |
| 1169 | Ile | Leu | Val | Val | Val | Val | Ile |
| 1204 | Met | Met | Met | Met | Met | Phe | Ile |
| 1224 | Val | His | His | Met | Phe | Leu | Met |
| End of the pocket factor | |||||||
| 1118 | Val | Ile | Tyr | Phe | Leu | Leu | Ile |
| 1120 | Ile | Met | Ile | Phe | Phe | Phe | Ile |
| 1130 | Ile | Tyr | Ala | Tyr | Ile | Ile | Ala |
| 1132 | Phe | Tyr | Tyr | Phe | Tyr | Tyr | Phe |
| 1154 | Pro | Ala | Pro | Pro | Pro | Pro | Ala |
| 1156 | Val | Val | Val | Val | Val | Ile | Val |
| 1167 | Phe | Phe | Phe | Val | Met | Ile | Met |
| 1207 | Leu | Leu | Met | Phe | Leu | Leu | Leu |
| 3024 | Ile | Ala | Ala | Ile | Ala | Ala | Val |
Residues are numbered based on RV-C15a numbering. In analogy with EV that have a pocket factor bound in the VP1 pocket, RV-C15a residues that are close to the head, the middle part, and the end of the pocket factor are indicated.