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. Author manuscript; available in PMC: 2016 Aug 11.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2013 May 29;14:215–243. doi: 10.1146/annurev-genom-091212-153448

Figure 4.

Figure 4

The respective contributions of host and microbe genetics to the clinical outcome of infectious diseases. An individual with a strong genetic vulnerability (e.g., owing to a single-gene variant) may develop clinical disease following infection with a weakly virulent microbe, whereas an individual with a low level of genetic vulnerability may develop clinical disease only if infected with a highly virulent microbe. The infection process itself is genetically controlled, with resistant and susceptible individuals.