Fig. 3.
Comparison of cross-links in C3(H2O) and C3. A, The 94 cross-links quantified from the C3(H2O) versus C3 comparison fall into five groups: C3-unique (10), C3-enriched (1), C3(H2O)-C3 mutual (57), C3(H2O)-enriched (4) and C3(H2O)-unique (22). B, The 57 C3(H2O)-C3 mutual cross-links are displayed (as dark gray rods) on the crystal structure of C3 (PDB 2A73), reflecting the presence of similar structural features. C, Ten C3-unique cross-links (blue rods), one C3-enriched cross-link (cyan rod), four C3(H2O)-enriched cross-links (dark green rods) and 22 C3(H2O)-unique cross-links (green rods) are displayed on the crystal structure of C3, suggesting the locations of structural differences between C3(H2O) and C3. ANA is colored in light blue.