Skip to main content
. Author manuscript; available in PMC: 2016 Aug 3.
Published in final edited form as: Nat Immunol. 2013 Jun 16;14(8):785–792. doi: 10.1038/ni.2631

Figure 4. Platelets aggregate after MRSA infection in vivo.

Figure 4

(a) Quantification of the number of platelet aggregates per field of view (FOV) within liver sinusoids that were larger than 25 μm2 following sham, Methicillin-susceptible S. aureus (MSSA; Xen29) or Methicillin-resistant S. aureus (MRSA; USA300) infection in wild-type mice. n ≥ 4 individual mice per group; error bars, SEM; *P < 0.05 by one-way ANOVA. (b) Representative 3-D reconstructed images showing KC (blue) captures green MSSA (left panel) or MRSA (right panel) and initiates platelet aggregation (red) within liver sinusoids after 10 min of infection in vivo. Yellow arrows denote the captured bacteria by KC within liver sinusoids. (c) Survival rate of MSSA or MRSA-infected wild-type mice treated with control (Ctrl) or platelet depletion serum (Platelet-depl). n ≥ 9 per group. *P < 0.01.