Table 1.
Effect of acute AM251 administration at 1 mg/kg on sucrose (8%) intake on day 5 after 4-day drinking-in-the-dark (DID) model in C57BL/6J mice. The groups assigned as the vehicle-treated or AM251-treated mice had similar sucrose intake 24 hours before the test day (data not shown). On the test day, 8% sucrose was presented 10 min after a single i.p. injection of AM251 or vehicle, and then sucrose intake values were recorded at 4 hours. The mice were assigned to one of 2 treatment groups: (1) vehicle as control; and (2) 1 mg/kg AM251. The values presented in the Table are mean ± SEM.
| Vehicle N = 7 |
1 mg/kg AM251 N = 8 |
|
|---|---|---|
| 8% sucrose, g/kg/4h | 19 ± 3 | 18 ± 2 |