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. Author manuscript; available in PMC: 2016 Dec 20.
Published in final edited form as: Nat Neurosci. 2016 Jun 20;19(8):992–994. doi: 10.1038/nn.4327

Figure 2.

Figure 2

Normalized correlations between instantaneous theta amplitude across a range of shifts between LFPs recorded in hippocampus (HPC) and prefrontal cortex (mPFC). Group average lag/lead relations during accurate performance following learning in the context exploration (a,c) and object sampling (b,d) periods. (a,b) Correlations between LFP amplitude patterns in HPC and mPFC over a series of temporal shifts for each trial phase. Shading indicates S.E.M. across sessions (n=21). (a) During context exploration the HPC lead significantly differed from zero (Wilcoxon signed-rank test, z21 = 4.02, p = 5.95e−5). (b) During object sampling the direction of functional connectivity reversed (z42 = 3.92, p = 8.83e−5) such that PFC led HPC (z21 = 3.93, p = 8.52e−5). (c–d) Sliding 1 s correlation windows advanced at 200 ms temporal shifts throughout the occurrence each trial phase. Dotted line denotes (c) the moment of entry into a context and (d) the onset of object sampling. White dots indicate peak correlation for each window.