Table 2.
Orthologous proteins that are yeast-prion-like in both Saccharomyces cerevisiae and Human
| NQ-rich proteins (NQPs) | ||||
| Yeast gene ID | Yeast gene name | Descriptiona | Human orthologsb | # of species with NQP orthologsc |
| YLL013C | PUF3 | Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also functions in mRNA degradation | PUM1 (ENSP00000257075, ENSP00000400141), PUM2 (ENSP00000409905) | 16 (30) |
| YGL237C | HAP2 | Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression | NFYA (ENSP00000229418, ENSP00000345702) | 12 (24) |
| YOR194C | TOA1 | TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo | GTF2A1 (ENSP00000409492, ENSP00000452454) | 10 (26) |
| YFL024C | EPL1 | Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy | EPC2 (ENSP00000258484) | 9 (17) |
| YNL251C | NRD1 | RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3′-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts | SCAF4 (ENSP00000382703) | 5 (7) |
| Prion predictions | ||||
| Yeast gene ID | Yeast gene name | Descriptiona | Human orthologs | # of species with orthologous prion predictionsb |
| YLR191W | PAS20 | Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins | PEX13 (ENSP00000295030) | 15 (19) |
| YNL016W | PUB1 | Poly (A) + RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress. The human ortholog associated with Welandar distal myopathy | TIA1 (ENSP00000404023) | 14 (23) |
| YLL013C | PUF3 | See above | PUM1 (ENSP00000400141, ENSP00000257075) | 13 (30) |
aThese descriptions are adapted from text on the UniProt [37] and SGD databases [49]
bThe gene names are followed by the Ensembl protein names for the orthologous proteins
cTotal number of the species listed in Table 1 that contain orthologous prion predictions or NQPs, with the total number of orthologs (regardless of whether they have a prion-like domain or not) in brackets