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Estrogens and androgens regulate metabolic function. (1) Androgens and estrogens act on the hypothalamus, mainly in ARC and VMH, regulating food intake, energy expenditure and locomotor activity. This action impacts on the metabolic function of liver, pancreas, adipose tissue and muscle, leading to the regulation of body weight and whole-body metabolic function. Moreover, (2) androgens and estrogens can directly modulate the function of those tissues.
