Figure 4.
Horizontal sections show the distribution of delaminating saccular cells and various markers. Note that the NT-3lac Zneo-positive cells (A,B) emigrate from the saccular anlage (S) to aggregate near the forming cochleo-vestibular ganglion (G). The sensory neurons have a distinct morphology (C) and are positive for α-acetylated tubulin (B) and trkB (D). In contrast, the delaminating cells (labeled “primordia”) are positive for NT-3lac Zneo (A,B) but not for tubulin (B) or trkB (D). Fibers to the saccule are passing between these cells in a fascicle (F) surrounded by lacZ-positive precursors. Bar indicates 100 μm.