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. Author manuscript; available in PMC: 2016 Jun 29.
Published in final edited form as: Nat Neurosci. 2016 Feb;19(2):198–205. doi: 10.1038/nn.4220

Figure 4. Proposed neurocircuit-wiring diagram based on optogenetic studies.

Figure 4

LHA GABAergic neurons inhibit VTA GABAergic neurons to disinhibit VTA dopamine neurons. Dopamine is release within the NAc where it excites D1R expressing MSNs and induces plasticity. These inhibitory signals then feedbacks to inhibit LHA GABAergic neurons to terminate feeding bouts. BNST GABAergic neurons preferentially inhibit LHA Glutamate neurons, some of which may project to the lateral habenula.