Figure 4.
GFAP–TK rats treated with GCV show a suppression in adult neurogenesis in the DG and exhibit a resting preference for a familiar rat. A, Timeline for neuronal birthdating, drug treatment, and behavioral testing for GFAP–TK rats. B, Left, Representative image of ventral DG of GFAP–TK rat treated with vehicle (Veh; top) or GCV (bottom) for a 2 week period. Red, BrdU; green, NeuN; blue, Hoechst 33342. Right, GFAP–TK rats treated with GCV showed a suppression in BrdU+ neurons in the DG. C, GFAP–TK rats with a suppressed pool of 6-week-old neurons show no impairments to recognizing a novel rat but exhibit a resting preference for a familiar rat. Values >0 indicate a preference for the novel rat; values <0 indicate a preference for the familiar rat. D, GFAP–TK rats with a suppressed pool of 6-week-old neurons prefer to rest near the familiar rat after investigation of either side. Bars indicate mean + SEM. *p < 0.05, **p < 0.01.