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. 2016 Jun 28;6:28686. doi: 10.1038/srep28686

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Copyright © 2016, Macmillan Publishers Limited

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Phosphosensing residues, whose mutation strongly decreased binding are highlighted in blue in (a) and (b) on pre-activated arrestin p44¹³. (a) Phosphosensitive residues deployed by Meta II-P (K14, K15, K20, R29, K110, K300 and H301) are located along the side of the arrestin N-domain. Side view (left) and top view (right) of arrestin are shown. The top view represents the orientation of arrestin as seen from the cytoplasmic face of the receptor. (b) Phosphosensing residues deployed by Ops-P (K14, K15, R18, K55, R56, R81, K150, K166, R171 and K300) are located in the cup of the arrestin N-domain. Views of arrestin are as in (a). (c) The phosphosensitive residues (blue) determined from the Meta II-P functional map are plotted on the Ops*/arrestin-1 complex¹⁴. The receptor is cyan, and the dashed line indicates the membrane plane. (d) The receptor phosphopeptide (Rpp) (mint green) aligned on arrestin. The Rpp model is adapted from⁹. N326, shown as sticks, is the last resolved residue in¹⁴ and is also shown as sticks in the Rpp model.