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. 2016 Jun 14;8:15. doi: 10.3389/fnsyn.2016.00015

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Copyright © 2016 Tang, Thevathasan, Lin, Lim, Kuroda, Kaibuchi, Bilger, Soong and Fivaz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DISC1 silencing by RNAi slows down SV exocytosis. (A) Immunoblot analysis of DISC1 in mouse hippocampal neurons (DIV 8) transduced with scramble, DISC1-A and DISC1-E shRNAs. (B) Average vGpH traces derived from neurons expressing scr (1204 boutons, 18 fields), -E (960 boutons, 18 fields) and -A (924 boutons, 16 fields) shRNAs from six independent experiments. (C,D) Analysis of SV exocytosis after Baf treatment. (C) Exocytic profiles of neurons expressing the indicated shRNAs. (D) Boxplot of exocytic rates. (E,F) Analysis of SV endocytosis. (E) Endocytic profiles. (F) Boxplot of endocytic rates. (G) Exocytic profile of cells expressing the indicated shRNAs in response to a stimulation (1200 APs, 10 Hz) that depletes the total releasable pool.