Figure 3. Plasma and CSF Aβ in different diagnostic groups with pathological CSF signature.
Plasma (A–C, Simoa immunoassay) and CSF (D–F, Euroimmun immunoassay) levels of Aβ42, Aβ40 and the Aβ42/Aβ40 ratio in patients with SCD (n = 60), MCI (n = 121), AD (n = 53) and controls (n = 74) with pathological (P) CSF amyloid signature compared to controls with normal (N) CSF amyloid signature (n = 200). Data are presented as mean ± 95% confidence interval (CI); p values are from univariate general linear models controlling for age and gender; statistical significance was set to p < 0.005 (0.05/10) to account for Bonferroni correction. AD, Alzheimer’s disease; CSF, cerebrospinal fluid; SCD, subjective cognitive decline; MCI, mild cognitive impairment.