Figure 5. Ectopic expression of miR-326 suppresses tumor growth in vivo.
(A) Tumor volume in nude mice. (B) Tumor weight in nude mice. Each group contained six mice (n = 6); the data are presented as the mean ± SEM; *p < 0.001, compared with the NC group. (C) The expression of cyclin D1 protein and mRNA in nude mice. Assays were performed in triplicate. Means ± SEM are shown. Statistical analysis was conducted using student t-test. (D) Immunohistochemistry showed miR-326 decreased the proliferation index Ki67. Statistical analysis was conducted using student t-test.