. 2016 May 12;2016:4684268. doi: 10.1155/2016/4684268

Table 1.

NK cell infiltrate in solid tumors.

Tumor	NK cell infiltrate: phenotype	NK cell infiltrate: size and/or location	Ref.
Lung adenocarcinoma	Reduced expression of NKp30, NKp46		[34]
Lung adenocarcinoma	Enrichment of CD56^bright Perf^low poorly cytotoxic NK cells		[35]

Non-small cell lung cancer	CD56^brightCD16^dim infiltrating NK cells with impaired killing capability		[36]
Non-small cell lung cancer	Infiltrating CD56^dim with low activating NK-rec expression and function	NKp46⁺ cells mainly localized at the invasive margin	[37]

Melanoma (primary)		Moderate/low CD56⁺CD3⁻ cells	[32]

Melanoma (primary/metastases)		Low CD56⁺NKG2D⁺ NK cells	[38]

Melanoma (metastases)		Low CD56⁺ NK cells	[21]

Melanoma (nodal/skin metastases)		CD56⁺ NK cells rarely present in melanoma	[39]

Melanoma (nodal metastases)	NKp30, NKG2D expression inversely correlated with number of tumor cells in the LN	NK cells surround tumor cell cluster	[40]

Melanoma (nodal metastases)		Enrichment of CD56^dim KIR⁺CD57⁺ cytotoxic NK cells	[41]

Colorectal cancer		Scarce NKp46⁺ infiltrating NK cells (despite high levels of chemokines)	[42]

Colorectal cancer	Reduced NKp46, NKp30, DNAM-1 expression		[43]

Colorectal cancer (lung metastases)		Low NKp46⁺ NK cell infiltrate	[44]

Breast cancer	Expression/function of NKp30, NKG2D in infiltrating NK cells decreases with disease progression		[45]

Breast cancer	Enrichment of CD56^bright Perf^low poorly cytotoxic NK cells		[35]

Renal cell carcinoma (lung metastases)		High NKp46⁺ NK cell infiltrate correlates with improved survival	[44]

GIST (GastroIntestinal Stromal Tumors)		Substantial NKp46⁺ NK cell infiltrate mainly surrounding tumor nests	[46]

GIST (GastroIntestinal Stromal Tumors)		Low NK cell infiltration/high metastases at diagnosis	[46]

GIST (GastroIntestinal Stromal Tumors)		High NK cell infiltration/prolonged progression-free survival after imatinib treatment	[47]