Figure 2.
Impaired working memory after RSD. A, Representative time line of working memory assessment in the MWM. Mice were subjected to six cycles of RSD or left undisturbed as CONs. Working memory was examined for 5 d (D7–D11) after completion of RSD (n = 10). B, In this paradigm, the escape platform was moved to a different quadrant each testing day. C, Representative paths for CON and RSD mice in the MWM on day 3. Velocity (D), latency to the platform (E), distance traveled (F), and percentage time in the outer annulus (G) were determined for all 5 testing days. Graphs represent the mean ± SEM. *p < 0.05, means are significantly different from CONs; #p = 0.06–0.10, means tended to be different from CONs.