Fig. 4.
(A) Epileptiform activity recorded 1 and 2 h after initiation of continuous bath application of 4AP from a combined mouse hippocampus-EC slice. Note that ictal (dotted line) and fast-developing interictal (arrows) activity is recorded at 1 h; at 2 h of 4AP application, ictal discharges disappear. (B) Spontaneous epileptiform activity induced by super fusing a combined mouse hippocampus-EC slice with Mg2+-free medium before and after Schaffer collateral cut. Note that before the lesion (top panel), interictal discharges are recorded from all limbic structures, while after sectioning the Schaffer collaterals (bottom panel) interictal discharges disappear in the EC and ictal activity, which is recorded in the three areas, is disclosed.