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. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: Nature. 2016 Mar 10;531(7593):258–262. doi: 10.1038/nature17194

Figure 2. Structural details of the TPC1 monomer.

Figure 2

Structure and domain boundaries in TPC1. a, A diagram describing the arrangement of structural domains, colored to match the structures below. Helices are depicted as cylinders and loops as lines. Structural details of TPC1 b, domain I and c, domain II from three perpendicular views. Phosphorylation sites are shown (*). Charges in S4 (++), S10 (++++), poly-E (----) in CTDh1, poly-R (++++) in CTDl1, and CxxCxxC (CCC) are shown. Ca2+ ions are shown in green and NED19 binding site shown as a purple hexagon.