Figure 4.
AZD1480 and gemcitabine treatment enhances tumor drug delivery. MALDI-MS/MS analysis of pancreatic tumor xenograft tissues was conducted to detect the presence of AZD1480 and Gem within the tumor. The optical image column demonstrates tissues prior to matrix coating; the H&E column contains stained serial sections. The MALDI-MS/MS images are divided into two columns, the first demonstrating detection of AZD1480 (m/z 255 and 257) and the second demonstrating detection of Gem (m/z 112). (A) MS images of the localization of AZD1480 and Gem in subcutaneous xenograft tissue sections. (B) MS images of the localization of AZD1480 and Gem in orthotopic xenograft tissue sections. The combination of AZD1480 and Gem results in enhanced in vivo delivery of both drugs in pancreatic tumor xenografts. The color scale ranges from blue to red, with red representing high concentration and blue representing low concentration of drug detected.