Fig. 2.
Mice fed KD for 60 weeks have sustained changes in metabolic rate and glucose homeostasis. KD-fed mice have a higher metabolic rate of VO2 consumption (A). The cyclic nature of the respiratory exchange rate (RER) is lost in the KD-fed mice (B) due to constant utilization of lipid as a fuel source. An indirect measure of heat (C) trends higher in the KD mice. The values for VO2 consumption, RER and heat all represent group means (±SEM, group size CH, n = 8; KD, n = 7). Mice fed KD for 60 weeks maintain glucose tolerance as measured by an IP glucose tolerance test (D). The values represent group means (±SEM, group size CH, n = 8; KD, n = 7). Mice fed KD for 60 weeks remain insulin-sensitive as shown by an ITT either by glucose level (E) or %change (F). The values represent group means (±SEM, group size CH, n = 7; KD, n = 5). Two-way Repeat Measures ANOVA for all datasets in this figure, significance is designated by asterisks with *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.