Table 1. Branch-site tests for positive selection on spike (S) protein by comparing foreground MERS-CoV (from human and camel) with background MERS-CoV (from bat and hedgehog).
| lnL MA’ | lnL MA | P value | Positively selected sites (PSS)# | ||
|---|---|---|---|---|---|
| S | −16251.74 | −16207.52 | <0.001 | 141R, 270Y*, 419S**, 436N*, 472S*, 479L*, 511R**, 521N*, 775S* | |
| N | −4449.82 | −4449.64 | p > 0.05 | NULL | |
| M | −2051.31 | −2051.14 | p > 0.05 | NULL | |
| E | −703.78 | −703.17 | p > 0.05 | 8Q, 11S, 56I | |
| 8 | −1022.67 | −1018.75 | p < 0.01 | NS | |
| 5 | −2583.27 | −2583.27 | p > 0.05 | NULL | |
| 4b | −2659.78 | −2659.76 | p > 0.05 | NULL | |
| 4a | −1056.27 | −1056.27 | p > 0.05 | NULL | |
| 3 | −1165.51 | −1165.50 | p > 0.05 | NULL |
#Only PSSs with post posterior probability (PP) > 0.9 are shown. *Means PP > 0.95, **means PP > 0.99. P value was estimated using χ2 tests with with degree of freedom = 1.