Table 5a.
Regression of M-value on SES Trajectories for Stress Pathway Genes (n = 1,231)
| Stress Pathway |
||||||||
|---|---|---|---|---|---|---|---|---|
|
AVP |
BDNF |
FKBP5 |
OXTR† |
|||||
| Beta(SE) | P-value | Beta(SE) | P-value | Beta(SE) | P-value | Beta(SE) | P-value | |
| Persistent Low SES* | −0.026(0.010) | 0.010 | 0.008(0.006) | 0.146 | −0.004(0.005) | 0.427 | 0.032(0.014) | 0.020 |
| Upward Mobility* | 0.006(0.012) | 0.626 | 0.008(0.007) | 0.240 | −0.0003(0.007) | 0.996 | 0.047(0.016) | 0.004 |
| Downward Mobility* | −0.006(0.010) | 0.568 | 0.004(0.005) | 0.519 | −0.005(0.005) | 0.324 | 0.019(0.013) | 0.155 |
| Promoter | 1.275 (0.006) | <0.0001 | −2.601(0.004) | <0.0001 | −0.217(0.007) | <0.0001 | — | — |
| Shore/Shelf | 3.003(0.013) | <0.0001 | −0.925(0.004) | <0.0001 | 0.225(0.008) | <0.0001 | 3.337(0.023) | <0.0001 |
| Persistent Low SES*Promoter | −0.036(0.008) | <0.0001 | −0.011(0.005) | 0.045 | −0.008(0.008) | 0.321 | — | — |
| Upward Mobility*Promoter | −0.028(0.010) | 0.0072 | −0.009(0.007) | 0.196 | −0.004(0.012) | 0.747 | — | — |
| Downward Mobility*Promoter | −0.023(0.009) | 0.0071 | −0.002(0.006) | 0.750 | 0.013(0.009) | 0.135 | — | — |
| Persistent Low SES*Shore/Shelf | 0.102(0.018) | <0.0001 | −0.002(0.005) | 0.659 | 0.022(0.008) | 0.007 | −0.072(0.029) | 0.012 |
| Upward Mobility*Shore/Shelf | 0.044(0.025) | 0.081 | −0.011(0.006) | 0.066 | 0.017(0.012) | 0.132 | −0.055(0.040) | 0.162 |
| Downward Mobility*Shore/Shelf | 0.068(0.019) | 0.0003 | −0.002(0.006) | 0.688 | 0.008(0.009) | 0.350 | −0.040(0.031) | 0.206 |
*
The reference category is persistent high SES.
†
For OXTR, all non-shore/shelf sites are also non-promoter sites, and all shore/shelf sites are also promoter sites.
Note: Models control for age, sex, race/ethnicity, and enrichment scores for each of 4 major blood cell types (neutrophils, B cells, T cells, and natural killer cells).