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. 2016 Mar 14;113(13):3651–3656. doi: 10.1073/pnas.1511974113

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Fig. 4. — NeuroLSD1^KO and neuroLSD1^HET hippocampi display reduced levels of H3K4 dimethylation and H3K9/K14 acetylation at the egr1 and c-fos promoters. Hippocampal chromatin from neuroLSD1^KO or neuroLSD1^HET mice or wild-type littermates was immunoprecipitated with anti-H3K4me2 and anti-H3K9/K14ac antibodies. Enrichments are shown as percentage of input. Shown is qPCR analysis at the level of egr1 (anti-H3K4me2: F_2,23 = 14.07, P = 0.0001; anti-H3K9/14ac: F_2,15 = 1.667, P = 0.2220) (A) or c-fos (anti-H3K4me2: F_2,28 = 19.74, P < 0.0001; anti-H3K9/14ac: F_2,22 = 4.379, P = 0.0251) (B) proximal promoters and the unrelated control (egr1 distal genomic region) (C) (n = 5–13 per condition). Data are shown as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001, one-way ANOVA, Tukey post hoc test; ^§P = 0.0269, Bartlett’s test.