Figure 2.
pDCs from patients with allergic asthma express increased surface FcεRIα, and this correlates inversely with influenza-induced IFN-α secretion. A, FcεRIα expression on pDCs was determined by flow cytometry (expressed as MESF) in the allergic asthma patient group and healthy control subjects. Results of t tests are displayed. Correlation between influenza A- and B-induced IFN-α release and pDC FcεRIα expression was determined (B and C, respectively). Significant inverse correlations are demonstrated for both influenza A- and influenza B-induced IFN-a secretion and pDC FcεRIα expression. Results of Pearson correlation tests are shown. Correlation between influenza A- and B-induced IFN-α release and serum IgE concentration was determined (D and E, respectively). Significant inverse correlations are demonstrated for both influenza A- and influenza B-induced IFN-α secretion and pDC FcεRIα expression. Results of Pearson correlation tests are shown.