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. 2015 Nov 25;7(2):1464–1476. doi: 10.18632/oncotarget.6386

Table 4. Association of DCLK1 with clinico-pathological features and biomarkers in IBC-NED.

DCLK1 IHC score
lo hi Total p-value Mean Median p-value
Grade 1 2 14 16 <0.001 5.8 (1.8) 7 (4.5-7) <0.001
2 17 52 69 4.9 (2.2) 6 (3.5-7)
3 28 22 50 3.3 (2.4) 3 (1.5-6)
Total 47 88 135
FF Absence 34 75 109 0.079 4.6 (2.4) 5 (2.5-7) 0.366
Presence 12 12 24 4.1 (2.4) 3.5 (2.5-6.5)
Total 46 87 133
necrosis Absence 39 76 115 0.440 4.5 (2.4) 5 (3-7) 0.463
Presence 7 9 16 3.9 (2.9) 4 (0.5-7)
Total 46 85 131
EIC Absence 39 71 110 0.645 4.4 (2.5) 5 0.841
Presence 7 16 23 4.7 (2.1) 5
Total 46 87 133
LVI Absence 20 59 79 0.006 4.8 (2.3) 5 (3-7) 0.093
Presence 24 25 49 4.0 (2.5) 4 (2-7)
Total 44 84 128
pN 0 16 47 63 0.001 4.9 (2.4) 6 (3-7) 0.012
1 15 25 40 4.2 (2.3) 4 (2-6)
2 6 7 13 4.0 (2.5) 4 (2-6.5)
3 10 4 14 2.9 (2.1) 3 (1.5-4)
Total 47 83 130
pT 1 14 39 53 0.028 5.0 (2.3) 6 (3-7) 0.042
2 29 42 71 4.0 (2.5) 4 (2-6)
3 1 2 3 5.3 (2.1) 6 (4.5-6.5)
4 3 1 4 2.8 (2.5) 2.5 (1-4.5)
Total 47 84 131
Molecular Lum A 14 60 74 <0.001 5.2 (2.1) 6 (4-7) <0.001
Lum B 28 26 54 3.5 (2.4) 3 (2-6)
HER2-OE 3 0 3 1.7 (1.5) 2 (0-3)
BLBC 0 0 0 - -
5NP 2 1 3 3.0 (3.0) 3 (0-3)
Total 47 87 134
Age Mean 56.6 59.7 58.7 0.249 - - -
SD 13.0 14.0 13.7 - -
Range 30-80 31-83
Tumor size Mean 2.86 2.58 2.68 0.208 - - -
SD 1.35 1.27 1.31 - -
Range 1.0-7.0 0.8-8.0
Biomarkers
ER Neg 6 3 9 0.065 2.8 (2.5) 3 (0-5.5) 0.031
Pos 41 85 126 4.6 (2.3) 5 (3-7)
Total 47 88 135
PR Neg 14 11 25 0.020 3.6 (2.2) 3 (2-5.5) 0.019
Pos 33 77 110 4.7 (2.4) 5 (3-7)
Total 47 88 135
AR Neg 28 52 80 0.957 5.2 (2.1) 5 (3-7) 0.458
Pos 19 36 55 4.7 (2.4) 5 (2-7)
Total 47 88 135
EGFR Neg 47 86 133 0.543 4.4 (2.4) 5 (3-7) 0.534
Pos 0 2 2 5.5 (2.2) 5.5 (4-7)
Total 47 88 135
HER2 Neg 37 84 121 0.002 4.6 (2.3) 6 (3-7) 0.002
Pos 10 3 13 3.7 (2.4) 3 (0-4)
Total 47 87 134
Ki67 low 21 63 84 0.002 4.9 (2.3) 6 (3.5-7) 0.004
high 26 25 51 3.7 (2.4) 3 (2-6)
Total 47 88 135
c-KIT Neg 41 83 124 0.152 4.5 (2.5) 5 (2-7) 0.501
Pos 6 5 11 4.2 (1.8) 3 (3-6)
Total 47 88 135
P63 Neg 45 88 133 0.343 4.5 (2.4) 5 (3-7) 0.263
Pos 1 0 1 2 2
Total 46 88 134
CK5/6 Neg 46 86 132 0.546 4.4 (2.4) 5 (3-7) 0.238
Pos 0 2 2 6.5 (0.7) 6.5 (6-7)
Total 48 88 134
CK14 Neg 46 87 133 1.0 4.5 (2.4) 5 (3-7) 0.933
Pos 1 1 2 4.5 (3.5) 4.5 (2-4.5)
Total 47 88 135
CG/SYN <50% 37 40 77 <0.001 3.7 (2.4) 4 (2-7) <0.001
≥50% 10 48 58 5.5 (2.1) 7 (5-7)
Total 47 88 135
p-Cadherin Neg 39 79 118 0.182 4.5 (2.4) 5 (3-7) 0.158
Pos 8 8 16 3.8 (2.4) 3.5 (2-6)
Total 47 87 134
Vimentin Neg 46 81 127 0.421 4.4 (2.4) 5 (2-7) 0.359
Pos 1 6 7 5.4 (1.5) 6 (4-7)
Total 47 87 134
CD44 Neg 8 24 32 1.0 5.3 (2.2) 6 (3.5-7) 0.376
Pos 5 13 21 4.7 (2.3) 5 (3.5-7)
Total 13 40 53
ALDH1 Neg 12 38 50 1.0 5.0 (2.2) 6 4-7) 0.573
Pos 1 2 3 5.7 (2.3) 7 (3-7)
Total 13 40 53
SOX2 Neg 8 32 40 0.179 5.2 (2.2) 6 (4-7) 0.261
Pos 5 8 13 4.5 (2.3) 4 (3-7)
Total 13 40 53

“SD”: standard deviation; “IQR”: Interquartile range