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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Feb 11;36(4):682–691. doi: 10.1161/ATVBAHA.116.307166

Figure 1. Loss of Id3 in B cells attenuates glucose intolerance and adipose tissue insulin resistance in DIO mice.

Figure 1

(A) Body and epididymal adipose tissue weights, and (B) GTT analysis in Id3Bcell KO and WT littermates fed standard chow (WT n=6; Id3Bcell KO n=9) or a HFD (WT n=10; Id3Bcell KO n=14). (C) Insulin-induced AKT phosphorylation in omental fat of WT and Id3Bcell KO littermates fed a HFD (n=3). (D) DIO μMT mice received either an i.p. vehicle (V, n=6) saline injection or adoptive transfer of 107 B-2 cells from DIO WT (n=7) or Id3−/− (n=7) donors and were continued on HFD for six additional weeks. (E) Body and epididymal adipose tissue weights. (F) GTT at two (left panel, representative of two independent experiments) and six (right panel, composite of two independent experiments) weeks post-transfer. Error bars represent ± SEM. *p<0.05, #p<0.05 WT vs. V.