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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Neuroimage. 2016 Feb 10;130:194–213. doi: 10.1016/j.neuroimage.2016.01.061

Table 2. Age modeled with and without controlling for sex, ethnicity, and supratentorial volume (svol).

Skeleton Regions No Covariates1 3 Covariates2 4 covariates3
Age
% Devian.
explained		 Age at
max FA
Confidence
Interval		 Age
% Devian.
explained		 Age at
max FA
Confidence
Interval		 Age
better
fit		 spline

p-value		 Age at
max FA
Confidence
Interval
GLOBAL MORI
SKELETON 		6.46 [17.82,17.91] 10.60 [18.15,18.25] spline 0.0003 [18.95,19.05]
COMMISSURAL FIBERS
Genu 1.60 [16.78,16.86] 3.89 [17.02,17.11] spline 0.0060 [17.65,17.74]
Body 2.74 [17.27,17.35] 5.17 [17.41,17.47] spline 0.0036 [18.53,18.62]
Splenium 1.35 [16.86,16.94] 3.89 [17.11,17.17] spline 0.0082 [21.91,21.95]
Tapetum 3.74 [21.91,21.95] 4.45 [21.91,21.95] spline 0.0393 [19.61,19.66]
PROJECTION FIBERS
Brainstem Tracts
Pontine Crossing Fibers 0.75 [21.91,21.95] 3.19 [21.91,21.95] linear 0.1653 [21.91,21.95]
Inferior Cerebellar Peduncle 6.56 [21.91,21.95] 12.50 [21.91,21.95] spline 0.0719 [21.91,21.95]
Middle Cerebellar Peduncle 2.30 [17.87,17.95] 7.07 [18.51,18.56] spline 0.0232 [21.91,21.95]
Superior Cerebellar
Peduncle		 5.03 [21.91,21.95] 16.60 [21.91,21.95] spline 0.1087 [21.91,21.95]
Cerebral Peduncle 15.70 [20.41,20.46] 19.01 [21.91,21.95] spline 0.0003 [21.91,21.95]
Corticospinal Tracts
Corticospinal Tract 6.20 [21.91,21.95] 8.36 [21.91,21.95] spline 0.0485 [21.91,21.95]
Medial Lemniscus 2.11 [21.91,21.95] 7.96 [21.91,21.95] spline 0.0383 [21.15,21.21]
Anterior Internal Capsule 7.78 [18.41,18.46] 17.00 [19.01,19.06] spline 0.0008 [19.41,19.45]
Poserior Internal
Capsule		 1.40 [17.21,17.27] 2.70 [17.41,17.47] spline 0.0131 [21.91,21.95]
Retrosplenial Internal
Capsule		 1.20 [17.61,17.67] 7.02 [19.75,19.84] spline 0.0609 [19.41,19.46]
Anterior Corona Radiata 2.76 [17.05,17.15] 6.06 [17.23,17.32] spline 0.0015 [18.21,18.26]
Superior Corona Radiata 3.12 [18.01,18.07] 3.87 [18.27,18.35] spline 0.0104 [19.81,19.86]
Poserior Corona Radiata 3.73 [18.05,18.14] 6.59 [18.17,18.25] spline 0.0056 [18.32,18.41]
Posterior Thalamic Radiation 2.69 [17.31,17.37] 5.50 [17.32,17.41] spline 0.0035 [17.35,17.44]
External Capsule 5.21 [18.21,18.26] 11.80 [18.84,18.93] spline 0.0036 [21.91,21.95]
ASSOCIATION FIBERS
Limbic Tracts
Fornix 0.00 [21.91,21.95] 2.89 [21.91,21.95] linear 0.3886 [21.91,21.95]
Stria Terminalis 4.13 [21.91,21.95] 10.50 [21.91,21.95] spline 0.0698 [21.91,21.95]
Anterior Middle Cingulum 7.15 [21.91,21.95] 14.40 [21.91,21.95] spline 0.0256 [21.91,21.95]
Inferior Cingulum 7.85 [21.91,21.95] 13.80 [21.91,21.95] spline 0.1252 [21.91,21.95]
Fasciculi
Superior Longitudinal
Fasciculus		 4.67 [17.91,17.97] 8.05 [18.11,18.15] spline 0.0019 [18.51,18.56]
Superior Frontal-Occipital
Fasciculus		 3.63 [17.53,17.62] 9.41 [18.04,18.13] spline 0.0035 [18.02,18.11]
Sagittal Stratum 3.35 [19.15,19.25] 7.53 [19.24,19.32] spline 0.0241 [20.01,20.06]
Uncinate Fasciculus 0.54 [21.91,21.95] 4.65 [21.91,21.95] linear 0.7327 [21.91,21.95]

Bold numbers indicate statistical significance based on adjustment for 28 comparisons, p≤.002; 99% confidence interval is listed for the age at maximum FA

1

No covariates entered into the model

2

Maximum FA determined from model including sex, ethnicity, and svol as covariates applied to harmonized scores

3

Maximum FA determined from model including sex, ethnicity, svol, and manufacturer as covariates applied to original scores