Extended Data Fig. 7. Additional human RanGAP1 and nup 107 pathology in C9-ALS brain.
(a) High power images of motor cortex reveals aberrant nuclear localization of RanGAP1 ,compared to non C9 control tissue, including various nuclear aggregate pathologies (right panels) (b) Aberrant RanGAP1 nuclear aggregates were not readily observed in C9-ALS cerebellar cortex molecular layer (ML), Purkinje cells (PK) or granule cell (GL) layer when compared to non C9-ALS control cerebellum. Number in upper right of each panel identifies autopsy specimen (Supplemental Table 2). (c) Nup107 was also aggregated at the nuclear membrane in C9-ALS motor cortex cells when compared to non C9-control tissues.