Figure 2.
Shortcomings of the ellipsoid assumption used in the diameter method of measuring a change in glioma size. (A) T1 contrast-enhanced MRI scan of a 55-year-old female with recurrent glioblastoma, before therapy initiation. (B) A scan from the same individual 26 days later. Note that the lesion has not only decreased in size but also in intensity of enhancement. According to the diameter-based cross-sectional area technique, the lesion has decreased to 72% of its original size, and would be classified in the stable disease category. On the basis of the volume of enhancement, the lesion is 35% of its original size, and would be classified as a partial response.